The landscape of medical care in North Texas has been profoundly shaped by institutions dedicated to pushing the boundaries of treatment, research, and education. Among these, a specific division within UT Southwestern Medical Center stands out for its significant contributions to patient care and medical advancement. This article explores the history, mission, and enduring impact of this pivotal group on north texas internal medicine, highlighting its journey from a specialized focus to a comprehensive leader in treating complex diseases and training future generations of physicians.
Understanding the evolution of such divisions provides insight into the growth and capabilities of healthcare services available in the region today. The dedication to integrating clinical expertise with cutting-edge scientific inquiry has been a hallmark, ensuring that patients in North Texas benefit from state-of-the-art medical knowledge and treatments.
The foundational goals established for the Division have consistently guided its development: promoting excellence in patient care, generating new knowledge relevant to specific disease areas, and training the next wave of physicians and physician-scientists. This three-part mission underscores a holistic approach to healthcare, recognizing that superior patient outcomes are inextricably linked to ongoing scientific discovery and the cultivation of skilled medical professionals.

The synergy between clinical practice and scientific research has been a deliberate strategy, leveraging UT Southwestern’s global reputation for scientific excellence to directly enhance the quality of patient care provided within the north texas internal medicine sphere and beyond. This integration ensures that the latest research findings are swiftly translated into practical clinical applications.
The Genesis and Early Years of a Medical Division
The origins of this significant division trace back to a strategic initiative to bolster medical specialization within UT Southwestern. Instituted by Donald C. Seldin, M.D., then Chair of the Department of Medicine, the Division formally began in 1962 with the appointment of Eugene P. Frenkel, M.D., as its first Director. From its inception, the program placed a strong emphasis on hematologic diseases, recognizing the critical need for advanced understanding and treatment in this area. This early focus laid the groundwork for future expansion and specialization.

An integral part of the initial program involved the integration and direction of the laboratory of nuclear medicine located at the Dallas Veterans Affairs Medical Center. This collaboration was crucial, providing unique opportunities to utilize radio isotopic techniques. These techniques were applied to study vital aspects of iron and B12 biology and metabolism, cell maturation and marrow egress, and red cell distribution and survival. This early engagement with advanced techniques demonstrated a forward-thinking approach to understanding disease mechanisms, a trait that would define the Division’s work in north texas internal medicine. The inter-institutional partnership also fostered a broader base for research and clinical application.
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Expanding its reach and expertise, the Division recruited Richard G. Sheehan, M.D., a noted disciple of William Damashek, M.D. Dr. Sheehan was tasked with directing and developing the program specifically at the VA Medical Center, further solidifying the Division’s presence and capabilities within a key healthcare facility in the region. The Division also benefited from multidisciplinary interactions right from its start, engaging with prominent figures in related fields.
This included collaboration with Tom Dutcher, M.D., Director of Hematopathology; Jack Pritchard, M.D., Chair of Obstetrics and Gynecology; and Frederick Bonte, M.D., Chair of Radiology/Radiation Therapy. Such cross-disciplinary engagement was vital for addressing the complex nature of cancer and blood diseases, reflecting a comprehensive approach to patient care that is essential for effective north texas internal medicine.
Specialized areas of focus were systematically developed through the recruitment of experts in specific domains. R. Graham Smith, M.D., was recruited from the National Cancer Institute to direct efforts in hematologic malignancies, a critical area requiring deep expertise. Mateel Graham, M.D., joined to direct the educational and clinical care programs, emphasizing the importance of training and direct patient service. The arena of hemostasis and coagulation was initiated and developed under the direction of Roger L. Bick, M.D., addressing another vital aspect of blood disorders. These strategic recruitments allowed the Division to build specialized pillars of excellence, enhancing its capacity to handle a wide range of complex conditions relevant to north texas internal medicine.
Growing Influence and Alumni Network in North Texas
The impact of the Division extends far beyond the immediate clinical and research activities within UT Southwestern. Its success in training physicians has had a ripple effect, contributing significantly to the broader medical community in the region. The very first fellow in the Division, Merrick Reese, M.D., went on to play a transformative role in the delivery of cancer care in North Texas.
Dr. Reese subsequently originated Texas Oncology and then U.S. Oncology. These organizations generated a broad network of physicians in clinical practice specifically in north texas internal medicine, particularly in the field of oncology. This expansion created widespread access to specialized cancer care throughout the region, directly linking the Division’s training efforts to tangible improvements in patient access and quality of care across North Texas. The legacy of the training program is clearly visible in the density and quality of medical specialists available regionally.
Leadership Transitions and Program Evolution
Like any dynamic institution, the Division has experienced transitions in leadership, each bringing new perspectives and strategic directions while building upon the established foundation. In 1991, John Minna, M.D., arrived at the University with the goal of developing the Cancer Center. In this capacity, he also took on the role of Director of the Division. These roles were complex, particularly with his concurrent work in developing the Lung Cancer SPORE (Specialized Programs of Research Excellence) and the Nancy B. and Jake L. Hamon Center for Therapeutic Oncology Research.

Due to the demands of developing these major research initiatives, Eugene P. Frenkel, M.D., who had been the first Director, took the helm of the Division once again. Subsequently, Richard Gaynor assumed the direction of the Cancer Center and later also the Division leadership. These transitions ensured continuity while integrating the Division’s work ever more closely with the burgeoning Cancer Center, a critical development for advancing cancer care within north texas internal medicine.
During this period of evolving leadership, significant subsectional focuses continued to develop and expand. Bone marrow transplantation emerged as a key area, later expanding into a comprehensive program in Hematologic Malignancies. The arena of Hemostasis and Coagulation also grew in prominence. When Dr. Gaynor left to become Vice President for Oncology Research at Eli Lilly, Sandra Hoffman, M.D., Ph.D., became Division Director. Concurrently, James V. Willson, M.D., was recruited from Case-Western Reserve University as the new Cancer Center Director. These leadership changes marked phases of strategic growth and further specialization, enhancing the Division’s capacity to provide advanced care in complex areas, vital for comprehensive north texas internal medicine services.
In 2007, a significant recruitment brought Joan Schiller, M.D., a world-renowned lung cancer clinician and investigator, to direct the Division. Her recruitment aimed to create a direct and close clinical, research, and educational link with the Cancer Center. This move underscored the strategic importance of integrating clinical practice with cutting-edge research, particularly in a high-impact area like lung cancer. Her leadership further cemented the Division’s role as a national leader with a direct positive impact on the standard of care for patients receiving north texas internal medicine treatment for complex diseases.
The Enduring Mission: Patient Care, Research, and Training
Throughout its history and across various leadership periods, the core mission of the Division has remained steadfast. The commitment to excellence in patient care forms the bedrock of its activities. This isn’t just about treating disease; it’s about providing compassionate, state-of-the-art care informed by the latest research. For patients seeking specialized north texas internal medicine for complex conditions, the Division serves as a beacon of hope and expertise. The clinical teams work tirelessly to offer advanced diagnostic techniques and therapeutic options, often participating in clinical trials that provide access to experimental treatments.
Generating new knowledge relevant to cancer and blood diseases is another critical pillar. The Division’s faculty are active researchers, delving into the molecular and cellular mechanisms of disease, identifying potential therapeutic targets, and developing novel treatment strategies. This research spans basic science discoveries to translational studies and clinical trials, directly contributing to the global understanding and treatment of these conditions. The integration of this research within the clinical environment ensures that patients benefit directly from scientific progress, a crucial advantage for north texas internal medicine provided by this institution.
Finally, the mission to train the next generation of physicians and physician-scientists is fundamental to the Division’s long-term impact. The fellowship programs are highly competitive, attracting talented individuals from across the country. These trainees receive rigorous education and hands-on experience in both clinical care and research. By nurturing future leaders in Hematology and Oncology, the Division ensures that the legacy of excellence in patient care, research, and education will continue to thrive, benefiting communities not only in North Texas but also nationwide. This commitment to education is vital for the future of north texas internal medicine specializations.
Conclusion
The history of this division at UT Southwestern Medical Center is a testament to sustained dedication in the fields of Hematology and Oncology. From its early focus on blood diseases and nuclear medicine techniques to its current status as a comprehensive center with specialized programs and renowned faculty, the Division has consistently been at the forefront of medical advancement. Its impact on north texas internal medicine is undeniable, seen not only in the direct patient care provided but also in the widespread network of skilled physicians trained within its programs and the significant contributions to medical knowledge through research.
The ongoing commitment to its core mission ensures that it will continue to play a vital role in shaping the future of specialized medical care, offering hope and healing to patients and training the leaders who will define the next era of north texas internal medicine and beyond.